A case of papillary squamotransitional carcinoma of the vagina is repo
rted. The immunohistochemical profiles (cytokeratin-7 and -20) and the
detection of human papillomavirus 16 support its close relationship t
o conventional squamous cell carcinoma. The lesion is compared to prev
iously reported cases of papillary transitional cell carcinoma of the
vagina and papillary squamotransitional cell carcinoma of the cervix.