SYNTHESIS, ANTIFUNGAL AND NEMATOCIDAL ACTIVITIES OF THIOUREINES WITH AN AMINOESTER SEQUENCE

Twenty-three arylthioureines bearing beta-alanine or gamma-aminobutyri c alkyl ester chains were synthesized for in vitro screening toward 44 strains of fungi and 2 genera of nematodes. The nitro derivatives wer e the most potent compounds against Aspergillus and Candida strains. E ster chains increase activity against the filarial worm Molinema desse tae. Twelve compounds have EC(50) < 40 mu g/ml. However, the anthelmin tic potency is weak compared with tetramisole.