SMI2-MEDIATED REDUCTION OF ALPHA-FUNCTIONALIZED AMIDES - HIGHLY ENANTIOSPECIFIC ACCESS TO AN ATROPISOMERIC AMIDE

Authors
HUGHES AD SIMPKINS NS
Citation
Ad. Hughes et Ns. Simpkins, SMI2-MEDIATED REDUCTION OF ALPHA-FUNCTIONALIZED AMIDES - HIGHLY ENANTIOSPECIFIC ACCESS TO AN ATROPISOMERIC AMIDE, Synlett, (9), 1998, pp. 967
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synlett → ACNP
ISSN journal
09365214
Issue
9
Year of publication
1998
Database
ISI
SICI code
0936-5214(1998):9<967:SROAA->2.0.ZU;2-F
Abstract
SmI2 or SmI2-LiCl mixtures can be used to reduce ol-functionalised ami des in yields of up to 85% depending upon the amide structure. The met hod has been applied to the synthesis of an atropisomeric anilide syst em in highly enantioenriched form, starting with (S)-O-acetyl lactic a cid.