SENNA - A SAFE AND EFFECTIVE DRUG

Senna consists of the dried leaves and fruits of Cassia acutifolia and C. angustifolia. The principal active constituents of senna are diant hrone glycosides whose aglycone is rhein. Rhein-induced laxative effec ts occur through two distinct mechanisms: an increase in intestinal fl uid transport and an increase in intestinal motility. Senna taken in r ecommended doses may lead to abdominal complaints whilst prolonged use causes melanosis coli. In recent years mutagenic effects of anthraqui none glycosides have been proven in in vitro tests, however studies in vivo do not confirm this for senna. (C) 1998 John Whey & Sons, Ltd.