RHEUMATOLOGIC MANIFESTATIONS OF GASTROINTESTINAL-DISEASES

One of the most significant extraintestinal manifestations of gastroin testinal diseases is rheumatologic disorders. The gastrointestinal dis eases with rheumatologic manifestations can be divided into two major categories: intestinal disorders and disorders of the liver, biliary t ree, and pancreas. The cause of diseases in each of these categories i s different. Although intestinal permeability and immune responsivenes s are frequently implicated in disorders of the intestine, diseases of the liver, biliary tree, and pancreas usually involve the production of autoantibodies, cytokines, or enzymes. Treatment of rheumatologic c omplications frequently involves therapy directed at the underlying ga strointestinal disease.