AS-183, A NOVEL INHIBITOR OF ACYL-COA - CHOLESTEROL ACYLTRANSFERASE PRODUCED BY SCEDOSPORIUM SP SPC-15549

Authors
KURODA K YOSHIDA M UOSAKI Y ANDO K KAWAMOTO I OISHI E ONUMA H YAMADA K MATSUDA Y
Citation
K. Kuroda et al., AS-183, A NOVEL INHIBITOR OF ACYL-COA - CHOLESTEROL ACYLTRANSFERASE PRODUCED BY SCEDOSPORIUM SP SPC-15549, Journal of antibiotics, 46(8), 1993, pp. 1196-1202
Citations number
13
Categorie Soggetti
Pharmacology & Pharmacy",Immunology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
46
Issue
8
Year of publication
1993
Pages
1196 - 1202
Database
ISI
SICI code
0021-8820(1993)46:8<1196:AANIOA>2.0.ZU;2-M
Abstract
A novel compound, AS-183, which inhibits acyl-CoA: cholesterol acyltra nsferase (ACAT), was isolated from the culture broth of a fungus, Sced osporium sp. SPC-15549. AS-183 inhibited ACAT activity in an enzyme as say system using rabbit liver microsomes with an IC50 value of 0.94 mu M. AS-183 also inhibited cholesterol ester formation in HepG2, CaCo2, and THP-1 cells with IC50 values of 18.1, 25.5, and 34.5 muM, respecti vely.