MICROBIAL GLYCOSIDATION OF SOME ANTHRACYCLINE ANTIBIOTICS BY AN ANTIBIOTIC-NEGATIVE MUTANT OF ACLARUBICIN PRODUCER

Microbial conversion of anthracyclinone monosaccharides using aclarubi cin-negative mutant of Streptomyces galilaeus was found to produce ant hracyclinone disaccharides which had either rhodinose or 2-deoxyfucose as an additional sugar. By this conversion we obtained twelve new ant hracyclines from seven anthracyclines which had rhodosamine, N-monomet hyldaunosamine or daunosamine at C-7 as a glycosidic sugar. All produc ts had a reduced cytotoxic activity in comparison with those of parent compounds. However, some of them showed a therapeutically improved an titumor effects against L1210 leukemia in vivo.