SYNTHESIS AND BIOLOGICAL-ACTIVITY OF 3-(N-SUBSTITUTED PYRIDINIUM-4-THIOMETHYL)-7-ALPHA-FORMAMIDO CEPHALOSPORINS

Authors
GUEST AW ADAMS RG BASKER MJ BRAIN EG BRANCH CL HARRINGTON FP NEALE JE PEARSON MJ ZOMAYA II
Citation
Aw. Guest et al., SYNTHESIS AND BIOLOGICAL-ACTIVITY OF 3-(N-SUBSTITUTED PYRIDINIUM-4-THIOMETHYL)-7-ALPHA-FORMAMIDO CEPHALOSPORINS, Journal of antibiotics, 46(8), 1993, pp. 1279-1288
Citations number
10
Categorie Soggetti
Pharmacology & Pharmacy",Immunology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
46
Issue
8
Year of publication
1993
Pages
1279 - 1288
Database
ISI
SICI code
0021-8820(1993)46:8<1279:SABO3P>2.0.ZU;2-D
Abstract
The synthesis and antibacterial activity of a series of 3-(1-substitut ed pyridinium-4-thiomethyl)-7alpha-formamido cephalosporins is describ ed. All the derivatives showed good potency and stability to bacterial beta-lactamases. The antibacterial efficacy seen with the N-alkyl pyr idinium substituents was enhanced by the introduction of a catecholic side chain at C-7 and by preparation of N-(substituted amino)pyridiniu m derivatives.