S. Manikant et al., LOADING DOSE DIAZEPAM THERAPY FOR ALCOHOL-WITHDRAWAL STATE, Indian journal of medical research. Section B: Biomedical research other than infectious diseases, 98, 1993, pp. 170-173
Two dose regimens of diazepam, conventional dose and loading dose, wer
e randomly given for the treatment of alcohol withdrawal state in 21 a
nd 20 male subjects, respectively. Total dose of diazepam in conventio
nal and loading dose groups were 200 mg and 67 +/- 9.3 mg, respectivel
y. Clinical response was comparable in both the groups. None of the su
bjects developed diazepam related side effects.