STIMULATION OF GASTRIC-ACID SECRETION BY CENTRAL ADMINISTRATION OF FMRFAMIDE IN RATS

Authors
MUTHAL AV CHOPDE CT
Citation
Av. Muthal et Ct. Chopde, STIMULATION OF GASTRIC-ACID SECRETION BY CENTRAL ADMINISTRATION OF FMRFAMIDE IN RATS, Indian journal of medical research. Section B: Biomedical research other than infectious diseases, 98, 1993, pp. 185-187
Citations number
14
Categorie Soggetti
Medicine, Research & Experimental
Journal title
Indian journal of medical research. Section B: Biomedical research other than infectious diseases → ACNP
ISSN journal
09709568
Volume
98
Year of publication
1993
Pages
185 - 187
Database
ISI
SICI code
0019-5340(1993)98:<185:SOGSBC>2.0.ZU;2-G
Abstract
The possible role of centrally administered tetrapeptide FMRFamide (Ph e-Met-Arg-Phe-NH2) On gastric acid secretion in pylorus ligated rats w as investigated. Intracerebroventricularly administered FMRFamide stim ulated the gastric acid secretion in a dose-dependant manner. This sti mulatory effect was abolished by vagotomy and atropine pretreatment. T he presence of FMRFamide in rat brain and the ability of FMRFamide to stimulate gastric acid secretion suggest that FMRFamide plays a physio logical role in brain modulation of gastric acid secretion.