EFFECT OF TOXAPHENE TOXICITY ON ENZYME-ACTIVITY AND RESIDUE LEVELS INVITAL ORGANS OF GUINEA-PIG

Authors
CHANDRA J DURAIRAJ G
Citation
J. Chandra et G. Durairaj, EFFECT OF TOXAPHENE TOXICITY ON ENZYME-ACTIVITY AND RESIDUE LEVELS INVITAL ORGANS OF GUINEA-PIG, Indian journal of medical research. Section B: Biomedical research other than infectious diseases, 98, 1993, pp. 193-198
Citations number
26
Categorie Soggetti
Medicine, Research & Experimental
Journal title
Indian journal of medical research. Section B: Biomedical research other than infectious diseases → ACNP
ISSN journal
09709568
Volume
98
Year of publication
1993
Pages
193 - 198
Database
ISI
SICI code
0019-5340(1993)98:<193:EOTTOE>2.0.ZU;2-V
Abstract
Guineapigs exposed to acute and subacute levels of toxaphene revealed a marginal reduction in the body weight. There was a significant inhib ition of acetylcholinesterase and ATPases in the brain, liver and kidn ey. The effect of subacute toxicity of toxaphene resulted in an enhanc ement of cytochrome P450 and induction of aniline hydroxylase in liver and kidney. Biochemical investigations on the backbone revealed that toxaphene toxicity caused an increase in the calcium content and a dec rease in the collagen content significantly. Toxaphene was accumulated more in the liver than in the kidney as reflected by residue studies.