PHOTOAFFINITY LIGANDS FOR THE MU-OPIOID RECEPTOR

Authors
SIMON EJ FAN LQ HILLER JM SEYEDMOZAFFARI A SCHULTZ AG ARCHER S
Citation
Ej. Simon et al., PHOTOAFFINITY LIGANDS FOR THE MU-OPIOID RECEPTOR, Life sciences, 53(14), 1993, pp. 1173-1178
Citations number
23
Categorie Soggetti
Biology,"Medicine, Research & Experimental
Journal title
Life sciences → ACNP
ISSN journal
00243205
Volume
53
Issue
14
Year of publication
1993
Pages
1173 - 1178
Database
ISI
SICI code
0024-3205(1993)53:14<1173:PLFTMR>2.0.ZU;2-5
Abstract
Two affinity ligands, phenacetamido)14beta-hydroxy-7,8-dihydromorphino ne (4) and ydroxy-7,8-dihydro-N-cyclopropylmehtylnormophinone (5) bind reversibly to opioid receptors present in bovine caudate membranes an d photolyse in a range of wavelengths centered about 366 nm to produce wash-resistant binding to the mu receptor. At these wavelengths very little if any photodestruction of the mu receptor occurs over the 20 m inute period of irradiation at 0-degrees-C.