MECHANISMS AND IMPLICATIONS OF GENOMIC INSTABILITY AND OTHER DELAYED-EFFECTS OF IONIZING-RADIATION EXPOSURE

Recently there has been considerable interest in various delayed effec ts of radiation. These have the common property of showing a high and, in some instances, nonclonal transmission of 'damage' to distant prog eny which derive from apparently normal surviving cells and their desc endants. This means that conventional analysis and interpretation of l ong-term radiation damage in terms of mutations induced in DNA at the time of radiation exposure may be incorrect. Several reviews of this a rea have appeared in recent years which have described the historical development of this field. The aim of this commentary is to highlight areas of discussion, particularly concerning links between the various end-points, and to discuss some of the possible implications of genom ic instability for radiation carcinogenesis in general and for the set ting of radiation protection action limits in particular.