A CASE OF SYSTEMIC KARYOMEGALY ASSOCIATED WITH INTERSTITIAL NEPHRITIS

Authors
VADIAKA M SOTSIOU F KOUFOS C
Citation
M. Vadiaka et al., A CASE OF SYSTEMIC KARYOMEGALY ASSOCIATED WITH INTERSTITIAL NEPHRITIS, Annales de medecine interne, 149(5), 1998, pp. 291-294
Citations number
11
Categorie Soggetti
Medicine, General & Internal
Journal title
Annales de medecine interne → ACNP
ISSN journal
0003410X
Volume
149
Issue
5
Year of publication
1998
Pages
291 - 294
Database
ISI
SICI code
0003-410X(1998)149:5<291:ACOSKA>2.0.ZU;2-K
Abstract
A case of systemic karyomegaly is described for the first time in Gree ce. This rare disease entity was first described in 1979 by Mihatsh an d so far only nine cases have been reported. Typical clinical features are progressive renal failure in the third decade of life and recurre nt infections, mostly of the upper respiratory tract. Typical histolog ic findings are markedly enlarged and hyperchromic nuclei in tubular c ells of the nephron and interstitial fibrosis surrounding the atrophic tubules.