INHIBITION OF FUNGAL SPHINGOLIPID BIOSYNTHESIS BY RUSTMICIN, GALBONOLIDE-B AND THEIR NEW 21-HYDROXY ANALOGS

Authors
HARRIS GH SHAFIEE A CABELLO MA CUROTTO JE GENILLOUD O GOKLEN KE KURTZ MB ROSENBACH M SALMON PM THORNTON RA ZINK DL MANDALA SM
Citation
Gh. Harris et al., INHIBITION OF FUNGAL SPHINGOLIPID BIOSYNTHESIS BY RUSTMICIN, GALBONOLIDE-B AND THEIR NEW 21-HYDROXY ANALOGS, Journal of antibiotics, 51(9), 1998, pp. 837-844
Citations number
22
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology,"Biothechnology & Applied Migrobiology",Immunology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
51
Issue
9
Year of publication
1998
Pages
837 - 844
Database
ISI
SICI code
0021-8820(1998)51:9<837:IOFSBB>2.0.ZU;2-C
Abstract
The mode of action of the known antifungal macrolides rustmicin (1) an d galbonolide B (2) has been determined to be the inhibition of sphing olipid biosynthesis. A large scale fermentation and isolation process was developed for production of large quantities of rustmicin. New 21- hydroxy derivatives of both compounds were isolated from pilot scale f ermentations and were also produced by biotransformation of rustmicin and galbonolide B.