ENCOURAGING RESPONSE OF AN ADVANCED STEROID-CELL TUMOR TO GNRH AGONIST THERAPY

Background: Chemotherapy for steroid tumors of unspecified type has me t with limited success and the overall prognosis has been poor. Case: A patient with a virilizing steroid tumor, otherwise unspecified, with demonstrated progressive disease after surgical debulking. Treatment with multiagent chemotherapy failed, but the patient subsequently had a robust response to GnRH agonist therapy. Conclusion: GnRH analogue t reatment should be considered prior to cytotoxic chemotherapy in cases of steroid tumor, not otherwise specified. (Obstet Gynecol 1998;92: 6 61-3. (C) 1998 by The American College of Obstetricians and Gynecologi sts.)