The novel melampolides (11R)-11,13-dihydro-schkuhriolide (7), (11S)-11
,13-dihydro-schkuhriolide (8), and schkuhrioidiol (11), along with the
known constituents, frutescin (1), schkuhriolide (2), frutescinic aci
d (4), allo-schkuhriolide (5), and epoxyschkuhriolide (6) were isolate
d from the aerial parts of Schkuhria schkuhrioides. The structures of
the new compounds were determined by spectroscopic methods. Compounds
1, 2, 4, 5, and 6 displayed no significant cytotoxic or antimicrobial
activities.