IDENTIFICATION AND SYNTHESIS OF NOVEL CHLORINATED P-ANISYLPROPANOID METABOLITES FROM BJERKANDERA SPECIES

Analysis of the EtOAc extracts from the culture medium of Bjerkandera sp. BOS55 and B. fumosa revealed the presence of two novel chlorinated metabolites. Their structures were unambiguously established as eryth ro-1-(3', 5'-dichloro-4'-methoxyphenyl)-1,2-propanediol (2) and 1-(3'- chloro-4'-methoxyphenyl)-3-hydroxy (3) through synthesis of authentic samples and comparison of retention times and mass spectral data. The production of trametol (1) by Bjerkandera sp. BOS55 was also a new fin ding.