TREATMENT OF POLYCYSTIC OVARIAN DISEASE DURING ADOLESCENCE WITH ETHINYLESTRADIOL CYPROTERONE-ACETATE VERSUS A D-TR-6-LHRH ANALOG

OBJECTIVE: This study was undertaken to compare the clinical and endoc rinological results of two kinds of treatment on adolescents with poly cystic ovarian disease (PCOD). METHOD: Forty-five adolescents with PCO D were randomly allocated into two groups, treated either with ethinyl estradiol (EE)/cyproterone acetate (group A) or the GnRH analog D-Tr-6 -LHRH (group B). RESULT: No significant changes were detected on the b ody mass index and waist-hip circumference. A significant improvement of hirsutism was noticed in both groups of patients. A normal menstrua l period was recorded in group A adolescents while all group B patient s became amenorrheic. A favorable decrease of ovarian volume was detec ted in both groups. LH/FSH ratio and DELTA4-androstenedione serum leve ls were found significantly reduced in both groups in comparison to pr e-treatment levels. The comparison between the two groups, after 6 mon ths, showed significantly lower values of LH/FSH ratio in group B case s. CONCLUSION: Both forms of treatment are safe and effective to a var ious degree for the management of PCOD adolescents.