5 NEW WITHANOLIDES FROM WITHANIA COAGULANS

Phytochemical studies on the whole plant of Withania coagulans have re sulted in the isolation of five new withanolides, namely coagulins H, I, J, K and L (1-5). Their structures have been established as (17S,20 S,22R)-5 alpha,6 beta, 14 alpha, 15 alpha, 17,20-hexahydroxy-1-oxowith a-2,24-dienolide (1), (14R, 17S, 20S,22R)-5 alpha,6 7-trihydroxy-14,20 -epoxy-1-oxowitha-2,24-dienolide (2), (14R, 17R,20R,22R)-3 27-dihydrox y-14,20-epoxy-1-oxowitha-5,24-dienolide (3), (14R, 17R,20R,22R)-14, 20 -epoxy-3 O-beta-D-glucopyranosyl)-1-oxowitha-5,24-dienolide (4) and (1 4R, 17S,20S,22R)-14, 17,20-trihydroxy-3 O-beta-D-glucopyranosyl)-1-oxo witha-5,24-dienolide (5), respectively on the basis of spectroscopic t echniques.