USE OF ENZYMES IN PREPARATION OF ENANTIOPURE 1,4-DIHYDROPYRIDINES

Various chemoenzymatic routes to optically pure biologically active di hydropyridines are reviewed. The review is focused on influence on the biotransformation of the main in vivo enzymatic activity of the hydro lase (lipase, esterase, protease), the microorganism source of the lip ase and the substituents of the 1,4-dihydropyridine ring, as well as t he physicochemical properties of the solvent and the nature of the nuc leophile. The influence of these variables in the desymmetrisation of prochiral diesters or in the resolution of racemic compounds is analyz ed.