Ac. Trillat et al., SYNERGISTIC NEUROCHEMICAL AND BEHAVIORAL-EFFECTS OF FLUOXETINE AND 5-HT1A RECEPTOR ANTAGONISTS, European journal of pharmacology, 357(2-3), 1998, pp. 179-184
We studied the ability of WAY 100635 4-(2-methoxyphenyl)-1-piperazinyl
]-N-(2-pyridinyl) cyclo-hexanecarboxamide}, 0.5 mg/kg, i.v. and (-)-5-
Me-8-OH-DPAT -5-methyl-8-hydroxy-2-(di-n-propylamino)tetralin}, 3 mg/k
g, i.v. two selective 5-HT1A receptor antagonists, to potentiate: (1)
the enhancement of extracellular 5-HT levels ([5-HText]) induced by a
single administration of 5 mg/kg i.p. fluoxetine using in vivo microdi
alysis in the ventral hippocampus of conscious rats, (2) the decrease
in food intake induced by this antidepressant drug in food-deprived ra
ts. The effects of fluoxetine were significantly potentiated, by 30-40
%, by WAY 100635 as well as by (-)-5-Me-8-OH-DPAT in the two sets of e
xperiments. Thus, fluoxetine increased [5-HText] in serotonergic nerve
terminal areas and consequently, induced hypophagia, both effects bei
ng limited by indirect activation of somatodendritic 5-HT1A autorecept
ors. (C) 1998 Elsevier Science B.V. All rights reserved.