THE HUMAN SEROTONIN-7 RECEPTOR PSEUDOGENE - VARIATION AND CHROMOSOME LOCATION

We report a variation of the pseudogene for the serotonin-7 receptor i n human DNA. Human genomic DNA was amplified, using the polymerase cha in reaction method and degenerate oligonucleotide primers for serotoni n receptor-like genes. A novel gene DNA sequence of 1325 bp was found. Based on nucleotides, this gene is 88% identical to the serotonin-7 r eceptor coding sequence. Compared with the previously known serotonin- 7 receptor pseudogene, this pseudogene has I nucleotide deletion and 4 nucleotide mutations. The gene is located on human chromosome 12 at 1 2p 12.3-p13.2.