EFFECTS OF ANTIALLERGIC DRUGS ON HISTAMINE-RELEASE FROM RAT PERITONEAL MAST-CELLS INDUCED BY BRADYKININ

Effects of antiallergic drugs on bradykinin-induced histamine release and intracellular Ca2+ release from peritoneal mast cells were studied ill mrs. Bradykinin caused a concentration-dependent histamine releas e as well as Ca2+ release from the intracellular Ca store of peritonea l mast cells. Antiallergic drugs used in tills study showed an inhibit ion of not only histamine release but also Ca2+ release. The Ca2+ rele ase from the intracellular Ca store induced by bradykinin was more sen sitive to antiallergic drugs than histamine release from mast cells. M equitazine and terfenadine caused potent inhibitory effects oil both r esponses, whereas effects of ketotifen and cromolyn sodium were relati vely weak. In conclusion, histamine release from mast cells and intrac ellular C2+ release induced by bradykinin were inhibited by antiallerg ic drugs similar to those induced by substance P and compound 48/80. ( C) 1998 Prous Science. All rights reserved.