UV DERIVATIVE SPECTROPHOTOMETRIC ASSAY OF NICARDIPINE AND ITS PHOTODEGRADATION PRODUCT

Citation
G. Ragno et C. Vetuschi, UV DERIVATIVE SPECTROPHOTOMETRIC ASSAY OF NICARDIPINE AND ITS PHOTODEGRADATION PRODUCT, Die Pharmazie, 53(9), 1998, pp. 628-631
Citations number
18
Categorie Soggetti
Pharmacology & Pharmacy","Chemistry Medicinal",Chemistry
Journal title
ISSN journal
00317144
Volume
53
Issue
9
Year of publication
1998
Pages
628 - 631
Database
ISI
SICI code
0031-7144(1998)53:9<628:UDSAON>2.0.ZU;2-Q
Abstract
A fourth-order derivative spectrophotometric method was developed for a direct and simultaneous determination of nicardipine and its pyridin e photodegradation product, which also represents its main metabolite, in bulk and in pharmaceutics. The analyte concentrations were correla ted with spectral measurements through equations obtained by simple an d multiple regression analysis. The recovery values from synthetic mix tures were verified to be from 95 to 101% and the precision, expressed as RSD, under 3%. The determination and quantification limits of the photoproduct were found to be 0.2 and 0.8%, respectively. This method is suitable for uniformity content analysis in pharmaceutical preparat ions and stability tests in routine control.