STRUCTURAL SPECIFICITY OF SEROTONIN EFFECT ON HUMAN ERYTHROCYTE FRAGILITY

Authors
GILBOAGARBER N KIRSTEINSEGAL R
Citation
N. Gilboagarber et R. Kirsteinsegal, STRUCTURAL SPECIFICITY OF SEROTONIN EFFECT ON HUMAN ERYTHROCYTE FRAGILITY, MOLECULAR GENETICS AND METABOLISM, 64(4), 1998, pp. 283-285
Citations number
16
Categorie Soggetti
Genetics & Heredity","Medicine, Research & Experimental",Biology
Journal title
MOLECULAR GENETICS AND METABOLISM → ACNP
ISSN journal
10967192
Volume
64
Issue
4
Year of publication
1998
Pages
283 - 285
Database
ISI
SICI code
1096-7192(1998)64:4<283:SSOSEO>2.0.ZU;2-8
Abstract
Serotonin, a neurotransmitter and vasoconstrictor, affects various cel l properties. We have analyzed the importance of its structural compon ents for its extensive effect on human erythrocyte fragility, using it s O- and N-linked derivatives and related compounds. The results prese nted in this communication indicate that the amino group, free of adja cent negative charges, and the hydroxyl group are indispensable for th e serotonin-induced increase in red blood cell fragility. (C) 1998 Aca demic Press.