METHAMPHETAMINE - PROPERTIES AND ANALYTICAL METHODS OF ENANTIOMER DETERMINATION

Methamphetamine is one of the most frequently abused drugs of today. D ue to its stereogenic center, it can exist as single enantiomer. Like many other chiral compounds, methamamphetamine enantiomers exhibit dif ferent pharmacological effects on living organisms. For this reason, i t is necessary to develop enantioselective and sufficiently sensitive methods of determination. This review focuses on methamphetamine with an accent on analytical chemistry and especially on chiral separations of this toxicologically important compound. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.