IN-VIVO EVALUATION OF REUTERIN AND ITS COMBINATIONS WITH SURAMIN, MELARSOPROL, DL-ALPHA-DIFLUOROMETHYLORNITHINE AND BLEOMYCIN IN MICE INFECTED WITH TRYPANOSOMA-BRUCEI-BRUCEI

Authors
YUNMBAM MK ROBERTS JF
Citation
Mk. Yunmbam et Jf. Roberts, IN-VIVO EVALUATION OF REUTERIN AND ITS COMBINATIONS WITH SURAMIN, MELARSOPROL, DL-ALPHA-DIFLUOROMETHYLORNITHINE AND BLEOMYCIN IN MICE INFECTED WITH TRYPANOSOMA-BRUCEI-BRUCEI, Comparative biochemistry and physiology. C. Comparative pharmacologyand toxicology, 105(3), 1993, pp. 521-524
Citations number
16
Categorie Soggetti
Biology,"Pharmacology & Pharmacy",Toxicology
Journal title
Comparative biochemistry and physiology. C. Comparative pharmacologyand toxicology → ACNP
ISSN journal
07428413
Volume
105
Issue
3
Year of publication
1993
Pages
521 - 524
Database
ISI
SICI code
0742-8413(1993)105:3<521:IEORAI>2.0.ZU;2-K
Abstract
1. Trypanosoma brucei brucei-infected mouse models treated with a new antibiotic, reuterin, showed reduction of the levels of parasitemia an d prolonged survival of the mice. 2. Cures of the parasitemia were obs erved in groups of mice treated with combinations of reuterin and sura min or melarsoprol. 3. Reuterin administered in combination with bleom ycin or DL-alpha-difluoromethylornithine showed temporary remission of the parasitemia in groups of mice.