STRUCTURE OF (S)-(+)-IBUPROFEN

Authors
FREER AA BUNYAN JM SHANKLAND N SHEEN DB
Citation
Aa. Freer et al., STRUCTURE OF (S)-(+)-IBUPROFEN, Acta crystallographica. Section C, Crystal structure communications, 49, 1993, pp. 1378-1380
Citations number
5
Categorie Soggetti
Crystallography
Journal title
Acta crystallographica. Section C, Crystal structure communications → ACNP
ISSN journal
01082701
Volume
49
Year of publication
1993
Part
7
Pages
1378 - 1380
Database
ISI
SICI code
0108-2701(1993)49:<1378:SO(>2.0.ZU;2-V
Abstract
(S)-(+)-Ibuprofen, alpha-methyl-4-(2-methylpropyl)-benzeneacetic acid, crystallizes with two molecules in the asymmetric unit to form a cycl ic hydrogen-bonded dimer. Within the dimer each molecule shows subtle conformational differences via rotations about the acetic C(1)-C(2) an d C(10)-C(11) bonds. Bond distances and angles for (S)-(+)-ibuprofen a re in close agreement with those found for the structure of the racemi c compound [McConnell (1974). Cryst. Struct. Commun. 3, 73-75].