3 MONOFLUORINATED SMALL MOLECULES - ORTHO-FLUOROPHENYLGLYCINE, METHYL4-(FLUOROCARBONYL)BENZOATE AND 16-ALPHA-FLUORO-ALPHA-ESTRADIOL 3-METHYL ETHER

Authors
BURNS JH HAGAMAN EW
Citation
Jh. Burns et Ew. Hagaman, 3 MONOFLUORINATED SMALL MOLECULES - ORTHO-FLUOROPHENYLGLYCINE, METHYL4-(FLUOROCARBONYL)BENZOATE AND 16-ALPHA-FLUORO-ALPHA-ESTRADIOL 3-METHYL ETHER, Acta crystallographica. Section C, Crystal structure communications, 49, 1993, pp. 1393-1396
Citations number
16
Categorie Soggetti
Crystallography
Journal title
Acta crystallographica. Section C, Crystal structure communications → ACNP
ISSN journal
01082701
Volume
49
Year of publication
1993
Part
7
Pages
1393 - 1396
Database
ISI
SICI code
0108-2701(1993)49:<1393:3MSM-O>2.0.ZU;2-I
Abstract
2-Amino-2-(2-fluorophenyl)acetic acid (ortho-fluorophenylglycine) cons ists of a planar acetate anion with a fluorophenyl group attached to t he alpha C atom at a dihedral angle of 105.5-degrees. All three amino H atoms form hydrogen bonds to carboxylate O atoms of three adjacent m olecules in the crystal. Methyl 4-(fluorocarbonyl)benzoate has a plana r phenylfluorocarbonyl group and its planar carboxylate group is rotat ed by 6-degrees from it. The estradiol 3-methyl ether, -fluoro-3-metho xyestra-1,3,5(10)-trien-17alpha-ol, has the well known structure for t he estradiol moiety. The alcoholic H atom is hydrogen bonded to the ad jacent F atom of the molecule. There are no intermolecular hydrogen bo nds.