NEW SYNTHESIS OF 1,4 BENZODIAZEPINE-2,5-DIONES BY MEANS OF HCL-GAS CATALYST

Authors
AKSSIRA M BOUMZEBRA M KASMI H DAHDOUH A ROUMESTANT ML VIALLEFONT P
Citation
M. Akssira et al., NEW SYNTHESIS OF 1,4 BENZODIAZEPINE-2,5-DIONES BY MEANS OF HCL-GAS CATALYST, Synthetic communications, 23(16), 1993, pp. 2265-2272
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
23
Issue
16
Year of publication
1993
Pages
2265 - 2272
Database
ISI
SICI code
0039-7911(1993)23:16<2265:NSO1BB>2.0.ZU;2-C
Abstract
A new synthesis of 1,4-benzodiazepinediones 4 , particularly 1,4-dihyd ro1H-1,4-benzodiazepine-2,5-dione,4c key intermediate of metabolites c yclopenin 9, cyclopenol 10, cyclopeptine 11 and dehydrocyclopeptine 12 , was achieved by action of dry HCl gas in DMF on compound 3 prepared from anthranilic acid derivative 1 and amino ester 2.