We define the Brauer group Br (G) of a locally compact groupoid G to b
e the set of Morita equivalence classes of pairs (A, alpha) consisting
of an elementary C-bundle A over G((0)) satisfying Fell's condition
and an action alpha of G on A by -isomorphisms. When G is the transfo
rmation groupoid X x H, then Br (G) is the equivariant Brauer group Br
-H (X). In addition to proving that Br (G) is a group, we prove three
isomorphism results. First we show that if G and H are equivalent grou
poids, then Br (G) and Br (H) are isomorphic. This generalizes the res
ult that if G and H are groups acting freely and properly on a space X
, say G on the left and H on the right, then Br-G (X/H) and Br-H (G\X)
are isomorphic. Secondly we show that the subgroup Br-0 (G) of Br (G)
consisting of classes [A,alpha] with A having trivial Dixmier-Douady
invariant is isomorphic to a quotient epsilon (G) of the collection Tw
(G) of twists over G. Finally we prove that Br (G) is isomorphic to t
he inductive limit Ext (G, T) of the groups epsilon (G(X)) where X var
ies over all principal G spaces X and G(X) is the imprimitivity groupo
id associated to X.