EFFICIENT SYNTHESIS OF ENANTIOPURE 1,2-BIS(HYDROXYMETHYL)-3,3-DIFLUOROCYCLOPROPANE DERIVATIVES THROUGH LIPASE-CATALYZED REACTION

Authors
ITOH T MITSUKURA K FURUTANI M
Citation
T. Itoh et al., EFFICIENT SYNTHESIS OF ENANTIOPURE 1,2-BIS(HYDROXYMETHYL)-3,3-DIFLUOROCYCLOPROPANE DERIVATIVES THROUGH LIPASE-CATALYZED REACTION, Chemistry Letters, (9), 1998, pp. 903-904
Citations number
18
Categorie Soggetti
Chemistry
Journal title
Chemistry Letters → ACNP
ISSN journal
03667022
Issue
9
Year of publication
1998
Pages
903 - 904
Database
ISI
SICI code
0366-7022(1998):9<903:ESOE1>2.0.ZU;2-9
Abstract
Efficient synthesis of chiral difluorocyclopropane building block has been accomplished; prochiral diacetate of 1,2-bis(hydroxymethyl)-3, 3- difluorocyclopropane was converted to the corresponding monoacetate th rough Alcaligenes sp. lipase-catalyzed hydrolysis with >99% enantiomer ic excess.