Ci. Stefanadis et al., RETROGRADE NONTRANSSEPTAL BALLOON MITRAL VALVULOPLASTY - IMMEDIATE RESULTS AND INTERMEDIATE LONG-TERM OUTCOME IN 441 CASES - A MULTICENTER EXPERIENCE, Journal of the American College of Cardiology, 32(4), 1998, pp. 1009-1016
Objectives. Our aim was to present the immediate and inter mediate lon
g-term results of the application of retrograde non transseptal balloo
n mitral valvuloplasty (RNBMV) in four cooperating centers from Greece
and India, Background. RNBMV is a purely transarterial method of ball
oon valvuloplasty, developed with the aim to avoid complications assoc
iated with transseptal catheterization. Only single-center experience
with RNBMV has been previously reported. Methods. The procedure was at
tempted in 441 patients with symptomatic mitral stenosis (320 women, 1
21 men, mean age [+/- SD] 44 +/- 11 years, mean echocardiographic scor
e [+/- SD] 7.7 +/- 2.0) from 1988 to 1996. Three hundred eighty-five p
atients with successful immediate outcome were followed clinically for
a mean [+/- SD] of 3.5 +/- 1.9 (range, 0.5-9.1) years. Results. A tec
hnically successful procedure was achieved in 388 (88%) cases. The ech
ocardiographic score (p < 0.001), male gender (p = 0.005), preprocedur
al mitral regurgitation (p 0.007) and previous surgical commissurotomy
(p = 0.029) were unfavorable predictors of immediate outcome. Complic
ations included death (0.2%), severe mitral regurgitation (3.4%) and i
njury of the femoral artery (1.1%), Event free (freedom from cardiac d
eath, mitral valve surgery, repeat valvuloplasty and NYHA class > II s
ymptoms) survival rates (+/- SEM) were 100%, 96.9 +/- 0.9%, 89.8 +/- 1
.9% and 75.5 +/- 5.5% at 1, 2, 4 and 9 years, respectively. The echoca
rdiographic score (p < 0.001), NYHA class (p = 0.008) and postprocedur
al mitral valve area (p = 0.009) mere significant independent predicto
rs of intermediate long-term outcome. Conclusions. Multicenter experie
nce indicates that RNBMV is a safe and effective technique for the tre
atment of symptomatic mitral stenosis. As with the transseptal approac
h, patients with favorable mitral valve anatomy derive the greatest im
mediate and intermediate long-term benefit from this procedure. (C) 19
98 by the American College of Cardiology.