Em. Grubman et al., CARDIAC DEATH AND STORED ELECTROGRAMS IN PATIENTS WITH 3RD-GENERATIONIMPLANTABLE CARDIOVERTER-DEFIBRILLATORS, Journal of the American College of Cardiology, 32(4), 1998, pp. 1056-1062
Objectives. We sought to utilize terminal stored intracardiac electrog
rams (EGMs) to study the electrophysiologic events that accompany mort
ality in patients with third-generation implantable cardioverter-defib
rillators (ICDs). Background. Despite their ability to effectively ter
minate ventricular tachyarrhythmias, cardiac mortality in patients wit
h ICDs remains high. The mechanisms and modes of death in these patien
ts are not well understood. Methods. We retrospectively analyzed clini
cal data and stored EGMs from patients enrolled in the clinical trial
of the Ventritex Cadence ICD. Of the 1,729 patients 119 died during 6
years of follow-up. The final recorded EGM was reviewed. Postimplant E
GMs as well as 50 control EGMs were used to define normal EGM characte
ristics. Results. There were 36 noncardiac deaths (30%) and 83 cardiac
deaths (70%). Of the cardiac deaths, 55 (66%) were nonsudden and 28 (
34%) were sudden. When cardiac deaths were analyzed, 46 (55%) had no s
tored EGMs within 1 h of death, implying that the deaths were not dire
ctly related to tachyarrhythmias. In 37 cardiac deaths (18 nonsudden,
19 sudden), stored EGMs were present within 1 h of death. In these 37
deaths, the final EGM recorded was nide (>158 ms) in 33 (89%). Wide EG
Ms were interpreted as ventricular tachycardia in 27 and ventricular f
ibrillation in 6. In 13 of the 33 patients (39%) with wide EGMs, thera
py was not delivered by the ICD, as it incorrectly detected a spontane
ous termination of the arrhythmia. EGMs were significantly wider if re
corded within 1 h, as compared with those recorded from 1 to 48 h befo
re death (261 +/- 124 vs. 181 +/- 93 ms, p = 0.04). Conclusions. Only
37 patients (31%) who died after placement of an ICD had a stored EGM
within I h of the time of death, suggesting that the majority of death
s (69%) were not the immediate result of a tachyarrhythmia, When EGMs
were recorded, they were wide in 89% of patients. These wide EGMs most
likely represent intracardiac recordings of electromechanical dissoci
ation. Thus, of the 119 deaths, 112 (94%) were not the immediate resul
t of a tachyarrhythmia. (C) 1998 by the American College of Cardiology
.