LABORATORY AND FIELD-EVALUATION OF THE REPELLENTS DEET, CIC-4, AND AI3-37220 AGAINST ANOPHELES FARAUTI (DIPTERA, CULICIDAE) IN AUSTRALIA

Laboratory and field tests of the repellents diethyl methylbenzanide ( deet), 1-(3-cyclohexen-1-yl-carbonyl)-2-methylpiperidine (AI3-37220), and (2-hydroxymethylcyclohexyl) acetic acid lactone (CIC-4) were condu cted against Anopheles farauti s.s. Laveran, an important malaria vect or in the southwest Pacific region. In the laboratory, An. farauti was tolerant of all 3 repellents, but deet and CIC-4 provided significant ly better protection than AI3-37220. The field study was conducted in rain Forest located near Innisfail, northern Queensland, and tested 25 % (vol:vol) ethanol solutions of each repellent against An. farauti. A ll 3 repellents provided >95% protection against An. farauti for 5 h a fter application. In contrast to the laboratory tests, protection prov ided by AI3-37220 was significantly better than that by either deet or CIC-4, and there was no difference between protection by deer and CIC -4. The protection by deet and CIC-4 declined 8 h after application an d provided less than or equal to 50% protection at 9 h. In contrast, A 13-37220 provided greater than or equal to 94% protection for 9 h.