PREDICTORS OF EFFICACY OF ANTIARRHYTHMIC THERAPY IN PATIENTS WITH MALIGNANT VENTRICULAR TACHYARRHYTHMIAS

According to results of testing of antiarrhythmic drugs which included electrophysiological study and 24-hour ECG monitoring 109 patients wi th proven malignant ventricular tachyarrhythmias were divided into 2 g roups: 63 patients (60%) for whom effective antiarrhythmic therapy was found and 45 patients (40%) resistant to any antiarrhythmic therapy. Twenty two parameters including history, clinical data, results of ele ctro-, echocardiography and radionuclide ventriculography, ets. were u sed for comparison of these groups. According to stepwise discriminant analysis the following parameters were independently related to resul ts of drug tests: heart failure NYHA class II or higher, age, QRS dura tion in sinus rhythm, possibility to terminate attack of tachycardia m edically, sex, presence of left ventricular aneurysm, left ventricular ejection fraction. Mathematical model of assessment of probability of positive or negative results of antiarrhythmic therapy was created. T he use of this model before drug testing allowed to predict with proba bility of 80,3% possibility to work out effective antiarrhythmic thera py. The model also allowed to select patients who needed nondrug treat ment.