Chaetochalasin A (1), a new bioactive fungal metabolite with a previou
sly undescribed ring system, has been isolated from an EtOAc extract o
f Chaetomium brasiliense (NRRL 22999). The structure of 1 was determin
ed by NMR experiments and single-crystal X-ray diffraction analysis. (
C) 1998 Elsevier Science Ltd. All rights reserved.