A NEW POTENT ANTIFUNGAL AGENT FROM ACTINOPLANES SP

Authors
CHU M TRUUMEES I MIERZWA R TERRACCIANO J PATEL M DAS PR PUAR MS CHAN TM
Citation
M. Chu et al., A NEW POTENT ANTIFUNGAL AGENT FROM ACTINOPLANES SP, Tetrahedron letters, 39(42), 1998, pp. 7649-7652
Citations number
4
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
42
Year of publication
1998
Pages
7649 - 7652
Database
ISI
SICI code
0040-4039(1998)39:42<7649:ANPAAF>2.0.ZU;2-#
Abstract
A novel antifungal agent, Sch 56036 (1), was isolated from the ferment ation culture broth of an Actinoplanes sp. Structure elucidation of 1 was accomplished by the analysis of spectroscopic data. Compound 1 was identified as a new polycyclic xanthone. Biological evaluation of 1 i ndicated that the compound possesses broad spectrum antifungal activit y against various yeasts and dermatophytes with geometric mean MIC val ues ranging from 0.017 similar to 0.031 mu g/mL, respectively. (C) 199 8 Elsevier Science Ltd. All rights reserved.