SYNTHESIS OF ALPHA-HETEROSUBSTITUTED GLYCINE DERIVATIVES FROM DIHALOETHANAMIDES

Authors
BAILEY PD BAKER SR BOA AN CLAYSON J ROSAIR GM
Citation
Pd. Bailey et al., SYNTHESIS OF ALPHA-HETEROSUBSTITUTED GLYCINE DERIVATIVES FROM DIHALOETHANAMIDES, Tetrahedron letters, 39(42), 1998, pp. 7755-7758
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
42
Year of publication
1998
Pages
7755 - 7758
Database
ISI
SICI code
0040-4039(1998)39:42<7755:SOAGDF>2.0.ZU;2-9
Abstract
A range of protected a-heterosubstituted analogues of glycine were syn thesised from starting materials of the type CHFX-CONHR [X = Cl, Br, I ; R = CH2Ph, (S)-CHMePh]; the final products included derivatives of g lycine possessing N, O, F or S in the alpha-position, and the first ex ample of a free alpha-fluoro-alpha-amino acid (alpha-fluorobetaine) wh ose structure was confirmed by X-ray crystal structure determination. (C) 1998 Elsevier Science Ltd. All rights reserved.