A simple and convenient synthetic approach to the new series of 1,2,3,
4,5,6,7,8-octahydro-1,6-naphthyridines 1a-j has been developed. This w
as achieved via a one-pot process combining metalated 4-piperidinonimi
ne alkylation and intramolecular cyclization. (C) 1998 Published by El
sevier Science Ltd. All rights reserved.