SOLID AND SOLUTION-PHASE COMBINATORIAL SYNTHESIS OF UREAS

Authors
NIEUWENHUIJZEN JW CONTI PGM OTTENHEIJM HCJ LINDERS JTM
Citation
Jw. Nieuwenhuijzen et al., SOLID AND SOLUTION-PHASE COMBINATORIAL SYNTHESIS OF UREAS, Tetrahedron letters, 39(42), 1998, pp. 7811-7814
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
42
Year of publication
1998
Pages
7811 - 7814
Database
ISI
SICI code
0040-4039(1998)39:42<7811:SASCSO>2.0.ZU;2-I
Abstract
An efficient parallel synthesis of ureas based on amino acids is descr ibed, both in solution and on solid phase. 1,1'-Carbonylbisbenzotriazo le 2 is used as the coupling reagent. The ureas 5 and 10 were obtained in high yield (80-100%) and purity (71-97%). (C) 1998 Elsevier Scienc e Ltd. All rights reserved.