CHEMICAL-PROPERTIES AND CYTOTOXIC ACTIVITY OF COMPLEXES OF PLATINUM(II) AND PALLADIUM(II) CONTAINING DMSO AND VARIOUS ANIONS - SYNTHESIS AND STRUCTURAL CHARACTERIZATION OF [PT(DMSO)(2)(O-2(CO)(2)CCH2CH2CH2)]

Treatment of cis-[Pt(dmso)(2)Cl-2] with 2 mol of KBr or KI leads to th e formation of the analogous dibromide or diiodide complexes. Treatmen t of [M(dmso)(2)Cl-2] [M = Pt (cis-) or Pd (trans-)] with AgNO3 (2 mol ) in H2O followed by 1 mol of potassium oxalate, maleate, cyclobutane dicarboxylate (CBDC), malonate or 2 mol of potassium cyclohexane carbo xylate or pivalate leads to the formation of the corresponding Pt-II a nd Pd-II carboxylate complexes. The single crystal X-ray structure det ermination of [Pt(dmso)(2)(CBDC)] has been discussed and compared with data on other related complexes. The in vitro cytotoxic activity of s ome of these complexes against eight tumour cell lines has been examin ed using the MTT-colorimetric assay.