FAST DRUG ANALYSIS BY CAPILLARY-ELECTROPHORESIS - CONTENT UNIFORMITY AND ASSAYS FOR DILTIAZEM TABLETS AND TRIMETOQUINOL TABLETS

We applied capillary electrophoresis (CE) to quantify and examine the content uniformity of ingredients of pharmaceutical formulations (dilt iazem hydrochloride tablets and trimetoquinol hydrochloride tablets), and also studied separation of enantiomers through the addition of dex trin or cyclodextrin (CD) as a chiral selector. We evaluated these met hods in the light of testing procedures and system suitability describ ed in the USP forum. The fast assay and content uniformity of both tab lets, including optical purity testing, were performed within 300 s. F rom the results of the system suitability testing, content uniformity and assay, these CE methods were found to be useful as an alternative to the conventional HPLC method.