CONSERVATION OF GENE ORDER - A FINGERPRINT OF PROTEINS THAT PHYSICALLY INTERACT

Authors
DANDEKAR T SNEL B HUYNEN M BORK P
Citation
T. Dandekar et al., CONSERVATION OF GENE ORDER - A FINGERPRINT OF PROTEINS THAT PHYSICALLY INTERACT, Trends in biochemical sciences, 23(9), 1998, pp. 324-328
Citations number
45
Categorie Soggetti
Biology
Journal title
Trends in biochemical sciences → ACNP
ISSN journal
09680004
Volume
23
Issue
9
Year of publication
1998
Pages
324 - 328
Database
ISI
SICI code
0968-0004(1998)23:9<324:COGO-A>2.0.ZU;2-7
Abstract
A systematic comparison of nine bacterial and archaeal genomes reveals a low level of gene-order (and operon architecture) conservation. Nev ertheless, a number of gene pairs are conserved. The proteins encoded by conserved gene pairs appear to interact physically. This observatio n can therefore be used to predict functions of, and interactions betw een, prokaryotic gene products.