SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIP OF SUBSTITUTED 1,2,3,4-TETRAHYDROISOQUINOLINES AS N-TYPE CALCIUM-CHANNEL BLOCKERS

Authors
YUEN PW SCHELKUN RM SZOKE B TARCZYHORNOCH K
Citation
Pw. Yuen et al., SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIP OF SUBSTITUTED 1,2,3,4-TETRAHYDROISOQUINOLINES AS N-TYPE CALCIUM-CHANNEL BLOCKERS, Bioorganic & medicinal chemistry letters, 8(18), 1998, pp. 2415-2418
Citations number
6
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
18
Year of publication
1998
Pages
2415 - 2418
Database
ISI
SICI code
0960-894X(1998)8:18<2415:SASROS>2.0.ZU;2-8
Abstract
Voltage Activated Calcium Channel (VACC) blockers have been demonstrat ed to have utility in the treatment of pain and stroke. A series of am inomethyl substituted isoquinolinol derivatives with potent functional activity for N-type VACC's have been identified. Their synthesis and preliminary pharmacology are discussed herein. (C) 1998 Elsevier Scien ce Ltd. All rights reserved.