A PHOTOACTIVATED PRODRUG

Authors
WEI YM YA YF PEI DH GONG B
Citation
Ym. Wei et al., A PHOTOACTIVATED PRODRUG, Bioorganic & medicinal chemistry letters, 8(18), 1998, pp. 2419-2422
Citations number
22
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
18
Year of publication
1998
Pages
2419 - 2422
Database
ISI
SICI code
0960-894X(1998)8:18<2419:>2.0.ZU;2-K
Abstract
A photolabile derivative (1) of the anticancer drug, 5-fluorodeoxyurid ine (2), was designed and synthesized as a model prodrug. Photolysis o f 1 with long-wavelength UV light rapidly released 2 in solution. Whil e compound 1 alone is nontoxic to cells, the presence of both 1 and UV irradiation (lambda = 350 nm) resulted in potent inhibition of cell g rowth. (C) 1998 Elsevier Science Ltd. All rights reserved.