DESIGN AND SYNTHESIS OF ANALOGS OF VITAMIN-E - ANTIPROLIFERATIVE ACTIVITY AGAINST HUMAN BREAST ADENOCARCINOMA CELLS

Authors
ARYA P ALIBHAI N QIN H BURTON GW BATIST G YOU SXL ALAOUIJAMALI MA
Citation
P. Arya et al., DESIGN AND SYNTHESIS OF ANALOGS OF VITAMIN-E - ANTIPROLIFERATIVE ACTIVITY AGAINST HUMAN BREAST ADENOCARCINOMA CELLS, Bioorganic & medicinal chemistry letters, 8(18), 1998, pp. 2433-2438
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
18
Year of publication
1998
Pages
2433 - 2438
Database
ISI
SICI code
0960-894X(1998)8:18<2433:DASOAO>2.0.ZU;2-H
Abstract
Analogs of alpha-tocopherol (vitamin E; compounds 3-9) have been synth esized and tested for their antiproliferative activity using the human breast cancer cell line, MCF7. Compounds 6-9 were synthesized from a common synthon, rac-Trolox (14) and are soluble/miscible at physiologi cal pH. Compounds 4, 8, and 9 were found to have antiproliferative act ivity at micromolar concentrations. (C) 1998 Elsevier Science Ltd. All rights reserved.