SYNTHESIS AND BIOLOGICAL EVALUATION OF 2 ANALOGS OF (S)-ALPHA-METHYL-3-CARBOXYPHENYLALANINE

Authors
MA DW MA ZC KOZIKOWSKI AP PSHENICHKIN S WROBLEWSKI JT
Citation
Dw. Ma et al., SYNTHESIS AND BIOLOGICAL EVALUATION OF 2 ANALOGS OF (S)-ALPHA-METHYL-3-CARBOXYPHENYLALANINE, Bioorganic & medicinal chemistry letters, 8(18), 1998, pp. 2447-2450
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
18
Year of publication
1998
Pages
2447 - 2450
Database
ISI
SICI code
0960-894X(1998)8:18<2447:SABEO2>2.0.ZU;2-K
Abstract
Two analogues 2, 3 of (S)-alpha-methyl-3-carboxylphenylalanine 1 were synthesized to test their activity for metabotropic glutamate receptor s (mGluRs). Both compounds 2 and 3 were inactive as antagonist for mGl uRs, but 2 showed weak agonistic activity for GluR6 in contrast to tha t reported by Kemp and co-workers. (C) 1998 Elsevier Science Ltd. All rights reserved.