THE DEVELOPMENT OF NOVEL AND SELECTIVE P56(LCK) TYROSINE KINASE INHIBITORS

Authors
BULLINGTON JL CAMERON JC DAVIS JE DODD JH HARRIS CA HENRY JR PELLEGRINOGENSEY JL RUPERT KC SIEKIERKA JJ
Citation
Jl. Bullington et al., THE DEVELOPMENT OF NOVEL AND SELECTIVE P56(LCK) TYROSINE KINASE INHIBITORS, Bioorganic & medicinal chemistry letters, 8(18), 1998, pp. 2489-2494
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
18
Year of publication
1998
Pages
2489 - 2494
Database
ISI
SICI code
0960-894X(1998)8:18<2489:TDONAS>2.0.ZU;2-3
Abstract
Early T-cell receptor mediated signal transduction involves the activa tion of several tyrosine protein kinases. One of these tyrosine kinase s, p56(lck), is expressed primarily in T-cells and Natural Killer (NK) cells and has been shown to be critical for their proliferative and e ffector functions. Indandiones have been identified as a potent and se lective chemical class that inhibits p56(lck). (C) 1998 Elsevier Scien ce Ltd. All rights reserved.